All Solid Tumors

Cancer Type

Tumor Tissue (FFPE)

Specimen Requirements

8 Working Days

Turnaround Time ¹

ACTDrug®+ is an NGS-based test, which sequences 40 druggable genes, 13 fusion genes, and more than 350 fusion transcripts simultaneously from cancer specimens.

Targeted Cancer Genomic Profiling Service

40

Cancer Genes

13

Fusion Genes

350

Fusion Transcripts

Hallmarks

Drug-Target-Based Panel

Sequences 40 actionable genes,13 fusion genes and more than 350 fusion transcripts with genetic alterations.

Short Turnaround Time

Provides professional solutions within 8 working days (starting from the date of receipt of approved samples at our CAP-accredited laboratory).

High Sensitivity

Uses the NGS platform for microscale specimens.

Tailored Drug Options

Analyzes single nucleotide variation (SNV), small insertion/deletion (InDel), copy number variation (CNV)and fusion gene to provide tailored drug options.

Pioneering Bioinformatics

Integrates cancer biology, medical biology, molecular biology, cell biology, immunology, bioinformatics, data science and pharmaceutical biology to provide insightful interpretation of the data analyses.

Summary

Select Drugs for Your Cancer Patient

Provides tailored drug options through precise genomic profiling for important actionable genes.

A Precise Choice for Cancer Genomic Profiling

ACTDrug®+ is a next-generation sequencing (NGS)-based assay, which sequences 40 actionable genes, 13 fusion genes and more than 350 fusion transcripts simultaneously from cancer specimens in our CAP-accredited laboratory. This assay is specially designed for patients with breast, lung, colorectal or gastric cancers, providing tailored genomic profiling and recommendations of targeted drugs approved by the US FDA.

Explore Various Genetic Alterations for More Precise Therapeutic Implication

ACTDrug®+ performs various genetic variation analyses. In addition to single nucleotide variation (SNV) and small insertion/ deletion (InDel), it provides copy number variation (CNV) analysis for 22 genes and fusion gene detection for more precise determination of potential implications.

For All Solid Tumors

Selects the most suitable treatment for newly diagnosed patients based on actionable genetic mutations.

Precise Reporting

Considers targeted therapies and hormonal therapies approved by US FDA or in clinical trials.

Technical Specifications

Next Generation Sequencing (NGS)

40 actionable genes

Specimen Requirements2

Tumor tissue (FFPE)

Sequencing Mean Depth

≥ 800 x

Hotspots

>3800

ACTFusion™

Comprehensive testing of 13 fusion genes and more than 350 fusion transcripts

Documentation

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Gene List Filter

Search
Cancer Type
Tier 1 Actionable Genes:

SNV / Indel

CNA

Fusion

*Genes also provide exon-skipping alteration information.

NTRK1/2/3

Breast

Colorectal

Gastric / GEJ

Biliary Tract

Brain (CNS)

SNV / Indel

ERBB2 (HER2)

Lung (NSCLC)

Breast

Colorectal

Gastric / GEJ

Biliary Tract

CNA

Fusion

RET

Lung (NSCLC)

Colorectal

Gastric / GEJ

Brain (CNS)

Breast

SNV / Indel

MET

Brain (CNS)

Colorectal

GIST

Breast

Lung (NSCLC)

CNA

KRAS

Thyroid

Brain (CNS)

Breast

Colorectal

Biliary Tract

Fusion

BRAF

GIST

Colorectal

Gastric / GEJ

Brain (CNS)

Biliary Tract

SNV / Indel

CNA

ROS1

Colorectal

Brain (CNS)

GIST

Lung (NSCLC)

Breast

SNV / Indel

Fusion

ALK

Breast

Colorectal

GIST

Brain (CNS)

Biliary Tract

CNA

Fusion

EGFR

Lung (NSCLC)

Brain (CNS)

Breast

Gastric / GEJ

SNV / Indel

CNA

Fusion

Other Relevant Genes:

MSH6

Lung (NSCLC)

Brain (CNS)

GIST

Colorectal

Breast

CNA

MSH2

Thyroid

Biliary Tract

Lung (NSCLC)

Brain (CNS)

GIST

SNV / Indel

CNA

Fusion

MLH1

Gastric / GEJ

Thyroid

Breast

Biliary Tract

Colorectal

SNV / Indel

Fusion

VHL

Brain (CNS)

GIST

Gastric / GEJ

Thyroid

Breast

Fusion

NF2

Lung (NSCLC)

Brain (CNS)

GIST

Gastric / GEJ

Thyroid

SNV / Indel

CNA

NF1

Biliary Tract

Colorectal

Lung (NSCLC)

Brain (CNS)

GIST

SNV / Indel

TSC2

Breast

Thyroid

Biliary Tract

Colorectal

Lung (NSCLC)

SNV / Indel

Fusion

TSC1

Breast

Gastric / GEJ

Thyroid

Biliary Tract

Colorectal

CNA

IDH2

Breast

Gastric / GEJ

Thyroid

Biliary Tract

Colorectal

SNV / Indel

IDH1

Lung (NSCLC)

Breast

Gastric / GEJ

Thyroid

Biliary Tract

SNV / Indel

CNA

ARID1A

Lung (NSCLC)

Colorectal

Breast

GIST

Gastric / GEJ

SNV / Indel

CTNNB1

Lung (NSCLC)

Colorectal

Breast

GIST

Gastric / GEJ

CNA

APC

Lung (NSCLC)

Colorectal

Breast

GIST

Gastric / GEJ

SNV / Indel

CNA

SMAD4

Lung (NSCLC)

Colorectal

Breast

GIST

Gastric / GEJ

SNV / Indel

Fusion

RB1

Lung (NSCLC)

Colorectal

Breast

GIST

Gastric / GEJ

CNA

Fusion

CDK6

Lung (NSCLC)

Colorectal

Breast

GIST

Gastric / GEJ

CNA

CDK4

Lung (NSCLC)

Colorectal

Breast

GIST

Gastric / GEJ

SNV / Indel

Fusion

CDKN2A

Brain (CNS)

Biliary Tract

Lung (NSCLC)

Colorectal

Breast

CNA

Fusion

STK11

Brain (CNS)

Biliary Tract

Lung (NSCLC)

Colorectal

Breast

SNV / Indel

PTEN

Brain (CNS)

Thyroid

Biliary Tract

Lung (NSCLC)

Colorectal

SNV / Indel

Fusion

RAD51C

Brain (CNS)

Thyroid

Biliary Tract

Lung (NSCLC)

Colorectal

SNV / Indel

CNA

Fusion

RAD51

Breast

Brain (CNS)

Thyroid

Gastric / GEJ

Biliary Tract

SNV / Indel

PALB2

Breast

Brain (CNS)

Thyroid

Gastric / GEJ

Biliary Tract

SNV / Indel

CNA

CHEK2

Breast

Brain (CNS)

Thyroid

GIST

Colorectal

Fusion

CHEK1

Breast

Gastric / GEJ

Brain (CNS)

Biliary Tract

Thyroid

SNV / Indel

ATR

Breast

Gastric / GEJ

Brain (CNS)

Biliary Tract

Thyroid

CNA

ATM

Colorectal

Breast

Gastric / GEJ

Brain (CNS)

Biliary Tract

SNV / Indel

NTRK1

Lung (NSCLC)

Colorectal

Breast

Gastric / GEJ

Brain (CNS)

SNV / Indel

CNA

PDGFRA

Lung (NSCLC)

Colorectal

Breast

Fusion

KIT

Lung (NSCLC)

Breast

Gastric / GEJ

Colorectal

Thyroid

CNA

FGFR3

Brain (CNS)

Biliary Tract

Lung (NSCLC)

Breast

CNA

FGFR2

Colorectal

GIST

Gastric / GEJ

Brain (CNS)

Biliary Tract

SNV / Indel

CNA

FGFR1

Colorectal

GIST

Gastric / GEJ

Brain (CNS)

Biliary Tract

Fusion

ERBB4

Colorectal

GIST

Lung (NSCLC)

Biliary Tract

Gastric / GEJ

SNV / Indel

CNA

Fusion

ERBB3

Breast

Colorectal

GIST

Lung (NSCLC)

Biliary Tract

Fusion

PIK3CA

Breast

Colorectal

GIST

Lung (NSCLC)

Biliary Tract

SNV / Indel

Fusion

NRAS

Breast

Colorectal

GIST

Brain (CNS)

Thyroid

CNA

EGFR

Breast

Colorectal

GIST

Lung (NSCLC)

Biliary Tract

Fusion

TP53

Breast

Colorectal

GIST

Brain (CNS)

Thyroid

SNV / Indel

Fusion

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Disclaimers / Footnotes

  1. Turnaround time starts from the date of receipt of approved samples at our CAP-accredited laboratory.
  2. Please refer to our specimen instructions.

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